Carolin A Müller

Carolin Müller

BBSRC Post-doc

Extraordinary Junior Research Fellow in Physiology, Queen's College.

Carolin was an undergraduate student at the University of Ulm, Germany. In 2008, she moved to the UK to take up a BBSRC-funded PhD Fellowship at the University of Nottingham as the Nieduszynski group’s first graduate student. Carolin developed and used novel state-of-the-art molecular technologies, mathematical modeling and computational programming to address fundamental biological questions about molecular inheritance. In 2013 and 2016, Carolin was awarded BBSRC-funded research grants as a co-investigator to continue her research in the Nieduszynski group at a post-doctoral level, first at the University of Nottingham and since 2014 at the Sir William Dunn School of Pathology, University of Oxford. In 2017, Carolin was elected the Extraordinary Junior Research Fellow in Physiology at the Queen’s College, Oxford.

During her PhD studies, Carolin’s primary research interests became directed toward understanding how biological information is passed from one generation to the next without error – the basis for all life on earth. Her recent work included the discovery that the time at which a gene replicates during S-phase can influence the gene’s expression level. Currently, Carolin’s research focuses on establishing a DNA sequencing-based method to detect replication fork movement on extremely long, single molecules.

  1. Tong, P, Pidoux, AL, Toda, NRT, Ard, R, Berger, H, Shukla, M, Torres-Garcia, J, Müller, CA, Nieduszynski, CA, Allshire, RC. Interspecies conservation of organisation and function between nonhomologous regional centromeres. Nat Commun. 2019;10 (1):2343. doi: 10.1038/s41467-019-09824-4. PubMed PMID:31138803 PubMed Central PMC6538654.
  2. Müller, CA, Boemo, MA, Spingardi, P, Kessler, BM, Kriaucionis, S, Simpson, JT, Nieduszynski, CA. Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads. Nat. Methods. 2019;16 (5):429-436. doi: 10.1038/s41592-019-0394-y. PubMed PMID:31011185 .
  3. Müller, CA, Nieduszynski, CA. DNA replication timing influences gene expression level. J. Cell Biol. 2017;216 (7):1907-1914. doi: 10.1083/jcb.201701061. PubMed PMID:28539386 PubMed Central PMC5496624.
  4. Shen, Y, Wang, Y, Chen, T, Gao, F, Gong, J, Abramczyk, D, Walker, R, Zhao, H, Chen, S, Liu, W, Luo, Y, Müller, CA, Paul-Dubois-Taine, A, Alver, B, Stracquadanio, G, Mitchell, LA, Luo, Z, Fan, Y, Zhou, B, Wen, B, Tan, F, Wang, Y, Zi, J, Xie, Z, Li, B, Yang, K, Richardson, SM, Jiang, H, French, CE, Nieduszynski, CA, Koszul, R, Marston, AL, Yuan, Y, Wang, J, Bader, JS, Dai, J, Boeke, JD, Xu, X, Cai, Y, Yang, H. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. Science. 2017;355 (6329):. doi: 10.1126/science.aaf4791. PubMed PMID:28280153 PubMed Central PMC5390853.
  5. Kobayashi, N, Suzuki, Y, Schoenfeld, LW, Müller, CA, Nieduszynski, C, Wolfe, KH, Tanaka, TU. Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres. Curr. Biol. 2015;25 (15):2026-33. doi: 10.1016/j.cub.2015.06.023. PubMed PMID:26166782 PubMed Central PMC4533239.
  6. Daigaku, Y, Keszthelyi, A, Müller, CA, Miyabe, I, Brooks, T, Retkute, R, Hubank, M, Nieduszynski, CA, Carr, AM. A global profile of replicative polymerase usage. Nat. Struct. Mol. Biol. 2015;22 (3):192-198. doi: 10.1038/nsmb.2962. PubMed PMID:25664722 PubMed Central PMC4789492.
  7. Hawkins, M, Retkute, R, Müller, CA, Saner, N, Tanaka, TU, de Moura, AP, Nieduszynski, CA. High-resolution replication profiles define the stochastic nature of genome replication initiation and termination. Cell Rep. 2013;5 (4):1132-41. doi: 10.1016/j.celrep.2013.10.014. PubMed PMID:24210825 PubMed Central PMC3898788.
  8. Müller, CA, Hawkins, M, Retkute, R, Malla, S, Wilson, R, Blythe, MJ, Nakato, R, Komata, M, Shirahige, K, de Moura, AP, Nieduszynski, CA. The dynamics of genome replication using deep sequencing. Nucleic Acids Res. 2014;42 (1):e3. doi: 10.1093/nar/gkt878. PubMed PMID:24089142 PubMed Central PMC3874191.
  9. Hoggard, T, Shor, E, Müller, CA, Nieduszynski, CA, Fox, CA. A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast. PLoS Genet. 2013;9 (9):e1003798. doi: 10.1371/journal.pgen.1003798. PubMed PMID:24068963 PubMed Central PMC3772097.
  10. Natsume, T, Müller, CA, Katou, Y, Retkute, R, Gierliński, M, Araki, H, Blow, JJ, Shirahige, K, Nieduszynski, CA, Tanaka, TU. Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol. Cell. 2013;50 (5):661-74. doi: 10.1016/j.molcel.2013.05.011. PubMed PMID:23746350 PubMed Central PMC3679449.
  11. Liti, G, Nguyen Ba, AN, Blythe, M, Müller, CA, Bergström, A, Cubillos, FA, Dafhnis-Calas, F, Khoshraftar, S, Malla, S, Mehta, N, Siow, CC, Warringer, J, Moses, AM, Louis, EJ, Nieduszynski, CA. High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome. BMC Genomics. 2013;14 :69. doi: 10.1186/1471-2164-14-69. PubMed PMID:23368932 PubMed Central PMC3599269.
  12. Müller, CA, Nieduszynski, CA. Conservation of replication timing reveals global and local regulation of replication origin activity. Genome Res. 2012;22 (10):1953-62. doi: 10.1101/gr.139477.112. PubMed PMID:22767388 PubMed Central PMC3460190.
  13. Siow, CC, Nieduszynska, SR, Müller, CA, Nieduszynski, CA. OriDB, the DNA replication origin database updated and extended. Nucleic Acids Res. 2012;40 (Database issue):D682-6. doi: 10.1093/nar/gkr1091. PubMed PMID:22121216 PubMed Central PMC3245157.
  14. Rhind, N, Chen, Z, Yassour, M, Thompson, DA, Haas, BJ, Habib, N, Wapinski, I, Roy, S, Lin, MF, Heiman, DI, Young, SK, Furuya, K, Guo, Y, Pidoux, A, Chen, HM, Robbertse, B, Goldberg, JM, Aoki, K, Bayne, EH, Berlin, AM, Desjardins, CA, Dobbs, E, Dukaj, L, Fan, L, FitzGerald, MG, French, C, Gujja, S, Hansen, K, Keifenheim, D, Levin, JZ, Mosher, RA, Müller, CA, Pfiffner, J, Priest, M, Russ, C, Smialowska, A, Swoboda, P, Sykes, SM, Vaughn, M, Vengrova, S, Yoder, R, Zeng, Q, Allshire, R, Baulcombe, D, Birren, BW, Brown, W, Ekwall, K, Kellis, M, Leatherwood, J, Levin, H, Margalit, H, Martienssen, R, Nieduszynski, CA, Spatafora, JW, Friedman, N, Dalgaard, JZ, Baumann, P, Niki, H, Regev, A, Nusbaum, C. Comparative functional genomics of the fission yeasts. Science. 2011;332 (6032):930-6. doi: 10.1126/science.1203357. PubMed PMID:21511999 PubMed Central PMC3131103.
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