Conrad A Nieduszynski

Conrad Nieduszynski

Principal Investigator

Wellcome Trust Investigator & Associate Professor of Cell Biology

Conrad undertook his PhD in Cambridge with Mark Carrington studying mouse cyclins. Then, he moved to Dundee for a post-doc with Anne Donaldson and Julian Blow where he started work on DNA replication. In 2007, Conrad was awarded a Leverhulme Early Career Fellowship to study the evolution of DNA replication origins. Then in 2008, Conrad was awarded a BBSRC David Phillips Fellowship with which he established his own research group at the University of Nottingham. His group continues to be generously funded by the BBSRC. In 2014, his group relocated to Oxford and in 2016 he was awarded a Wellcome Investigator grant. The group aims to determine how cells faithfully complete genome replication.

His research group has established high-throughput sequencing approaches to quantitatively measure at high resolution how genomes replicate.  Applying these method has allowed the discovery of mechanisms regulating DNA replication in diverse eukaryotic and prokaryotic cells. For example, in archaea, they discovered that accelerated growth can occur in the absence of DNA replication origins. In yeast, they have discovered mechanisms that ensure early centromere replication and how this contributes to faithful chromosome inheritance. Recently, Conrad’s group have established a genome sequencing method to measure replication fork movement on single molecules. This has provided the first whole genome single-molecule map of DNA replication dynamics.