Dima did his diploma studies at the Belarusian State University where his extracurricular laboratory work focused on increasing phenylalanine production by Brevibacterium flavum (now called Corynebacterium glutamicum) in the laboratory of Prof Natalia Maximova. His diploma project was carried out at the University of Edinburgh in the laboratory of Dr Eric Schirmer where Dima worked on Sun2 phosphorylation. After receiving a Darwin Trust of Edinburgh scholarship, Dima continued working on transmembrane nuclear envelope proteins during his PhD studies in the same laboratory. Dima discovered the role of several novel nuclear envelope proteins in adipogenesis and chromosome repositioning.
During his last years in Edinburgh, Dima’s interest in whole-genome sequencing grew and led to him realise that the technique can be used to study DNA replication. Using cutting-edge approaches to answer fundamental biological questions is the hallmark of the Nieduszynski laboratory and this convinced Dima to change his research focus to DNA replication. Following this tradition, Dima applied a novel, high-throughput digital PCR approach to study locus-specific DNA replication timing. His passion for standardising and simplifying research has led him to develop several analysis tools that are easy to use thanks to web-based GUIs. Check out our resources page for more information.
- Batrakou, DG, Heron, ED, Nieduszynski, CA. Rapid high-resolution measurement of DNA replication timing by droplet digital PCR. Nucleic Acids Res. 2018;46 (19):e112. doi: 10.1093/nar/gky590. PubMed PMID:29986073 PubMed Central PMC6212846.
- de Las Heras, JI, Zuleger, N, Batrakou, DG, Czapiewski, R, Kerr, AR, Schirmer, EC. Tissue-specific NETs alter genome organization and regulation even in a heterologous system. Nucleus. 2017;8 (1):81-97. doi: 10.1080/19491034.2016.1261230. PubMed PMID:28045568 PubMed Central PMC5287206.
- Batrakou, DG, de Las Heras, JI, Czapiewski, R, Mouras, R, Schirmer, EC. TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation. PLoS ONE. 2015;10 (5):e0127712. doi: 10.1371/journal.pone.0127712. PubMed PMID:26024229 PubMed Central PMC4449205.
- de Las Heras, JI, Meinke, P, Batrakou, DG, Srsen, V, Zuleger, N, Kerr, AR, Schirmer, EC. Tissue specificity in the nuclear envelope supports its functional complexity. Nucleus. ;4 (6):460-77. doi: 10.4161/nucl.26872. PubMed PMID:24213376 PubMed Central PMC3925691.
- Zuleger, N, Boyle, S, Kelly, DA, de las Heras, JI, Lazou, V, Korfali, N, Batrakou, DG, Randles, KN, Morris, GE, Harrison, DJ, Bickmore, WA, Schirmer, EC. Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. Genome Biol. 2013;14 (2):R14. doi: 10.1186/gb-2013-14-2-r14. PubMed PMID:23414781 PubMed Central PMC4053941.
- Korfali, N, Wilkie, GS, Swanson, SK, Srsen, V, de Las Heras, J, Batrakou, DG, Malik, P, Zuleger, N, Kerr, AR, Florens, L, Schirmer, EC. The nuclear envelope proteome differs notably between tissues. Nucleus. ;3 (6):552-64. doi: 10.4161/nucl.22257. PubMed PMID:22990521 PubMed Central PMC3515538.
- de Las Heras, JI, Batrakou, DG, Schirmer, EC. Cancer biology and the nuclear envelope: a convoluted relationship. Semin. Cancer Biol. 2013;23 (2):125-37. doi: 10.1016/j.semcancer.2012.01.008. PubMed PMID:22311402 .
- Korfali, N, Srsen, V, Waterfall, M, Batrakou, DG, Pekovic, V, Hutchison, CJ, Schirmer, EC. A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal. PLoS ONE. 2011;6 (4):e18762. doi: 10.1371/journal.pone.0018762. PubMed PMID:21533191 PubMed Central PMC3077400.
- Wilkie, GS, Korfali, N, Swanson, SK, Malik, P, Srsen, V, Batrakou, DG, de las Heras, J, Zuleger, N, Kerr, AR, Florens, L, Schirmer, EC. Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations. Mol. Cell Proteomics. 2011;10 (1):M110.003129. doi: 10.1074/mcp.M110.003129. PubMed PMID:20876400 PubMed Central PMC3016689.
- Korfali, N, Wilkie, GS, Swanson, SK, Srsen, V, Batrakou, DG, Fairley, EA, Malik, P, Zuleger, N, Goncharevich, A, de Las Heras, J, Kelly, DA, Kerr, AR, Florens, L, Schirmer, EC. The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture. Mol. Cell Proteomics. 2010;9 (12):2571-85. doi: 10.1074/mcp.M110.002915. PubMed PMID:20693407 PubMed Central PMC3101955.
- Malik, P, Korfali, N, Srsen, V, Lazou, V, Batrakou, DG, Zuleger, N, Kavanagh, DM, Wilkie, GS, Goldberg, MW, Schirmer, EC. Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope. Cell. Mol. Life Sci. 2010;67 (8):1353-69. doi: 10.1007/s00018-010-0257-2. PubMed PMID:20091084 PubMed Central PMC2839517.
- Batrakou, DG, Kerr, AR, Schirmer, EC. Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions. J Proteomics. 2009;72 (1):56-70. doi: 10.1016/j.jprot.2008.09.004. PubMed PMID:18852071 .