James Carrington

James Carrington

Wellcome Trust Post-doc

Jamie carried out his undergraduate degree on Molecular and Cellular Biology at the University of Edinburgh and graduated in 2013. He went on to carry out his PhD at the University of Dundee with Professor Julian Blow and submitted his thesis in 2017: “Post-Replicative Resolution of Under-Replication”. This work demonstrates that canonical DNA replication during S phase is not sufficient to complete genomic duplication in unperturbed human cells, and explores how human cells necessarily transmit the resultant unusual DNA structures through mitosis and beyond.

In the Nieduszynksi lab, Jamie is continuing research on the regulation of DNA replication and is currently working towards mapping and characterising the stochastic activity of replication origins and forks through S phase by detecting nucleotide analogue signal currents on extremely long nanopore traces (D-NAscent).

Outside of the lab, Jamie enjoys travelling, good food, films, rugby and trips to the pub.

  1. Gardner, NJ, Gillespie, PJ, Carrington, JT, Shanks, EJ, McElroy, SP, Haagensen, EJ, Frearson, JA, Woodland, A, Blow, JJ. The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines. Cell Chem Biol. 2017;24 (8):981-992.e4. doi: 10.1016/j.chembiol.2017.06.019. PubMed PMID:28781123 PubMed Central PMC5563080.
  2. Al Mamun, M, Albergante, L, Moreno, A, Carrington, JT, Blow, JJ, Newman, TJ. Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (39):E5765-74. doi: 10.1073/pnas.1603241113. PubMed PMID:27630194 PubMed Central PMC5047159.
  3. Moreno, A, Carrington, JT, Albergante, L, Al Mamun, M, Haagensen, EJ, Komseli, ES, Gorgoulis, VG, Newman, TJ, Blow, JJ. Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (39):E5757-64. doi: 10.1073/pnas.1603252113. PubMed PMID:27516545 PubMed Central PMC5047195.
  4. Wickstead, B, Carrington, JT, Gluenz, E, Gull, K. The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. PLoS ONE. 2010;5 (11):e15020. doi: 10.1371/journal.pone.0015020. PubMed PMID:21124853 PubMed Central PMC2990766.
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