Steph studied Cell and Molecular Biology at Oxford Brookes University. Following on from her work on H. influenzae during her degree, her early career focused on menigococcal interactions with host cells with Dr Mumtaz Virji at the University of Oxford. From there she moved to industry working on the VIVOST® fibrin sealant project at Oxford Bioresearch and then moved to the Oxford University spin out company Prolysis, lead by Professor Jeff Errington, where she continued her work with H. influenzae and early stage antibacterial development. Steph is now working in the Nieduszynski lab as a lab manager ensuring the smooth running of the group.
Steph is a member of the Athena Swan committee and outside the lab enjoys face painting and films.
- Palmer, JT, Axford, LC, Barker, S, Bennett, JM, Blair, M, Collins, I, Davies, DT, Ford, L, Gannon, CT, Lancett, P, Logan, A, Lunniss, CJ, Morton, CJ, Offermann, DA, Pitt, GR, Rao, BN, Singh, AK, Shukla, T, Srivastava, A, Stokes, NR, Thomaides-Brears, HB, Yadav, A, Haydon, DJ. Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors. Bioorg. Med. Chem. Lett. 2014;24 (17):4215-22. doi: 10.1016/j.bmcl.2014.07.037. PubMed PMID:25086682 .
- Axford, LC, Agarwal, PK, Anderson, KH, Andrau, LN, Atherall, J, Barker, S, Bennett, JM, Blair, M, Collins, I, Czaplewski, LG, Davies, DT, Gannon, CT, Kumar, D, Lancett, P, Logan, A, Lunniss, CJ, Mitchell, DR, Offermann, DA, Palmer, JT, Palmer, N, Pitt, GR, Pommier, S, Price, D, Narasinga Rao, B, Saxena, R, Shukla, T, Singh, AK, Singh, M, Srivastava, A, Steele, C, Stokes, NR, Thomaides-Brears, HB, Tyndall, EM, Watson, D, Haydon, DJ. Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors. Bioorg. Med. Chem. Lett. 2013;23 (24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. PubMed PMID:24239017 .
- Stokes, NR, Thomaides-Brears, HB, Barker, S, Bennett, JM, Berry, J, Collins, I, Czaplewski, LG, Gamble, V, Lancett, P, Logan, A, Lunniss, CJ, Peasley, H, Pommier, S, Price, D, Smee, C, Haydon, DJ. Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases. Antimicrob. Agents Chemother. 2013;57 (12):5977-86. doi: 10.1128/AAC.00719-13. PubMed PMID:24041906 PubMed Central PMC3837865.
- East, SP, White, CB, Barker, O, Barker, S, Bennett, J, Brown, D, Boyd, EA, Brennan, C, Chowdhury, C, Collins, I, Convers-Reignier, E, Dymock, BW, Fletcher, R, Haydon, DJ, Gardiner, M, Hatcher, S, Ingram, P, Lancett, P, Mortenson, P, Papadopoulos, K, Smee, C, Thomaides-Brears, HB, Tye, H, Workman, J, Czaplewski, LG. DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity. Bioorg. Med. Chem. Lett. 2009;19 (3):894-9. doi: 10.1016/j.bmcl.2008.11.102. PubMed PMID:19095445 .
- Stokes, NR, Sievers, J, Barker, S, Bennett, JM, Brown, DR, Collins, I, Errington, VM, Foulger, D, Hall, M, Halsey, R, Johnson, H, Rose, V, Thomaides, HB, Haydon, DJ, Czaplewski, LG, Errington, J. Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay. J. Biol. Chem. 2005;280 (48):39709-15. doi: 10.1074/jbc.M506741200. PubMed PMID:16174771 .
- Virji, M, Watt, SM, Barker, S, Makepeace, K, Doyonnas, R. The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae. Mol. Microbiol. 1996;22 (5):929-39. doi: 10.1046/j.1365-2958.1996.01548.x. PubMed PMID:8971714 .
- Stimson, E, Virji, M, Barker, S, Panico, M, Blench, I, Saunders, J, Payne, G, Moxon, ER, Dell, A, Morris, HR. Discovery of a novel protein modification: alpha-glycerophosphate is a substituent of meningococcal pilin. Biochem. J. 1996;316 ( Pt 1) :29-33. doi: 10.1042/bj3160029. PubMed PMID:8645220 PubMed Central PMC1217337.
- Stimson, E, Virji, M, Makepeace, K, Dell, A, Morris, HR, Payne, G, Saunders, JR, Jennings, MP, Barker, S, Panico, M. Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose. Mol. Microbiol. 1995;17 (6):1201-14. doi: 10.1111/j.1365-2958.1995.mmi_17061201.x. PubMed PMID:8594338 .