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DNA replication timing influences the expression level of some genes.

High-throughput sequencing reveals the dynamics of genome replication.

Recruitment of Dbf4-Cdc7 to the kinetochore promotes activation of proximal origins early in S phase.

A few replication origins differ in activity between closely related species, revealing that local sequence elements control origin activity.

Stochastic mathematical models aid in the interpretation of whole genome replication timing data.

OriDB: a DNA replication origin database for budding and fission yeasts.

Sequence conservation at replication origins reveals the location of the ORC-binding site.

Group members’ names in bold.

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  14. Newman, TJ, Mamun, MA, Nieduszynski, CA, Blow, JJ. Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res. 2013;41 (21):9705-18. doi: 10.1093/nar/gkt728. PubMed PMID:23963700 PubMed Central PMC3834809.
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  20. Guttery, DS, Ferguson, DJ, Poulin, B, Xu, Z, Straschil, U, Klop, O, Solyakov, L, Sandrini, SM, Brady, D, Nieduszynski, CA, Janse, CJ, Holder, AA, Tobin, AB, Tewari, R. A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog. 2012;8 (2):e1002554. doi: 10.1371/journal.ppat.1002554. PubMed PMID:22383885 PubMed Central PMC3285604.
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  23. Rhind, N, Chen, Z, Yassour, M, Thompson, DA, Haas, BJ, Habib, N, Wapinski, I, Roy, S, Lin, MF, Heiman, DI, Young, SK, Furuya, K, Guo, Y, Pidoux, A, Chen, HM, Robbertse, B, Goldberg, JM, Aoki, K, Bayne, EH, Berlin, AM, Desjardins, CA, Dobbs, E, Dukaj, L, Fan, L, FitzGerald, MG, French, C, Gujja, S, Hansen, K, Keifenheim, D, Levin, JZ, Mosher, RA, Müller, CA, Pfiffner, J, Priest, M, Russ, C, Smialowska, A, Swoboda, P, Sykes, SM, Vaughn, M, Vengrova, S, Yoder, R, Zeng, Q, Allshire, R, Baulcombe, D, Birren, BW, Brown, W, Ekwall, K, Kellis, M, Leatherwood, J, Levin, H, Margalit, H, Martienssen, R, Nieduszynski, CA, Spatafora, JW, Friedman, N, Dalgaard, JZ, Baumann, P, Niki, H, Regev, A, Nusbaum, C. Comparative functional genomics of the fission yeasts. Science. 2011;332 (6032):930-6. doi: 10.1126/science.1203357. PubMed PMID:21511999 PubMed Central PMC3131103.
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  26. Shor, E, Warren, CL, Tietjen, J, Hou, Z, Müller, U, Alborelli, I, Gohard, FH, Yemm, AI, Borisov, L, Broach, JR, Weinreich, M, Nieduszynski, CA, Ansari, AZ, Fox, CA. The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet. 2009;5 (12):e1000755. doi: 10.1371/journal.pgen.1000755. PubMed PMID:19997491 PubMed Central PMC2778871.
  27. Nieduszynski, CA, Donaldson, AD. Detection of replication origins using comparative genomics and recombinational ARS assay. Methods Mol. Biol. 2009;521 :295-313. doi: 10.1007/978-1-60327-815-7_16. PubMed PMID:19563113 .
  28. Chang, F, Theis, JF, Miller, J, Nieduszynski, CA, Newlon, CS, Weinreich, M. Analysis of chromosome III replicators reveals an unusual structure for the ARS318 silencer origin and a conserved WTW sequence within the origin recognition complex binding site. Mol. Cell. Biol. 2008;28 (16):5071-81. doi: 10.1128/MCB.00206-08. PubMed PMID:18573888 PubMed Central PMC2519699.
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  32. Müller-Tidow, C, Ji, P, Diederichs, S, Potratz, J, Bäumer, N, Köhler, G, Cauvet, T, Choudary, C, van der Meer, T, Chan, WY, Nieduszynski, C, Colledge, WH, Carrington, M, Koeffler, HP, Restle, A, Wiesmüller, L, Sobczak-Thépot, J, Berdel, WE, Serve, H. The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol. Cell. Biol. 2004;24 (20):8917-28. doi: 10.1128/MCB.24.20.8917-8928.2004. PubMed PMID:15456866 PubMed Central PMC517883.
  33. van der Meer, T, Chan, WY, Palazon, LS, Nieduszynski, C, Murphy, M, Sobczak-Thépot, J, Carrington, M, Colledge, WH. Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction. 2004;127 (4):503-11. doi: 10.1530/rep.1.00131. PubMed PMID:15047941 .
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  35. Cosgrove, AJ, Nieduszynski, CA, Donaldson, AD. Ku complex controls the replication time of DNA in telomere regions. Genes Dev. 2002;16 (19):2485-90. doi: 10.1101/gad.231602. PubMed PMID:12368259 PubMed Central PMC187453.
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